PROCESS FOR THE PREPARATION OF 2-BUTYL-4-CHLORO-5-FORMYLIMIDAZOLE
1150/MUM/2004 A (1150/MUM/2004)
Filed on 2004-10-27
Publication date 2007-02-09
Glycine is added to Methanolic Sodiumhydroxide solution at 30-35ºC followed by addition of Methylpentanimidate, from which Methanol is distilled out, residue is treated with Toluene, Phosphorous oxychloride and N, N- dimethyl formamide, this mixture is quenched in cold water; Hi-flow is added and pH is adjusted to 1.2 -1.3 by adding 30% aqueous sodium hydroxide solution, Hi-flow sludge obtained by filtration is washed with Toluene generating aqueous and toluene layer, which are separated and the toluene layer is washed twice with water; discarding water layer after each wash, finally toluene layer is obtainted in which carbon is added, mixture is filtered, wash with Toluene and filtrate consisting of Toluene is collected, concentrated to 50% volume by U/Vacuum at around 50-55ºC which is cooled to 0-5ºC and stirred; residue obtained after filtration is washed with chilled Toluene, dried at 50-55ºC to get crystalline 2-BUTYL-4CHLORO-5-FORMYLIMIDAZOLE.
Applicant
DISHMAN PHARMACEUTICAL AND CHEMICALS LIMITED
BHADR-RAJ CHAMBERS, C.G. ROAD, NAVRANGPURA, AHMEDABAD - 380 009 Gujarat India
Inventor
VYAS JANMEJAY RAJNIKANT, VARMA NIDADAVOLU VENKATA SATYA
International Information
Classification
C07D 233/54
Publication number
NA