The present invention concerns compounds of formula (I), and pharmaceutically acceptable salts or solvatcs thereof, or sol- vales of such salts, which compounds inhibit carboxypeptidase U and thus can be used in the prevention and treatment of diseases where in- (I) hibition of carboxypeptidase U is beneficial. In further aspects, the invention relates to compounds of the invention for use in therapy; to processes for preparation of such new compounds; to pharmaceutical compositions containing at least one compound of the invention, or a pharmaccutically acceptable salt or solvate thereof, as active ingredient; and to the use of the active compounds in the manufacture of medicaments for the medical use indicated above.