INDOLE ACETIC ACIDS EXHIBITING CRTH2 RECEPTOR ANTAGONISM AND USES THEREOF.
1395/KOLNP/2007 A (1395/KOLNP/2007)
Filed on 2007-04-19
Publication date 2007-07-20
The invention relates to indole acetic acid compounds which function as antagonists of the CRTH2 receptor. The mention also relates to the use of these compounds to inhibit the binding of prostaglandin D2 and its metabolites or certain thromboxane metabolites to the CRTH2 receptor and to treat disorders responsive to such inhibition.
Applicant
ATHERSYS, INC.
3201, CARNEGIE AVENUE, CLEVELAND, OHIO 44115-2634, UNITED STATES OF AMERICA U.S.A.
Inventor
BENNANI, YOUSSEF L., TUMEY, L. NATHAN, GLEASON, ELIZABETH ANN, ROBARGE, MICHAEL JOSEPH
International Information
Classification
C07D 417/04
Publication number
WO 2006/034419
Application date
2005-09-21
Application number
PCT/US2005/034029