CYCLOPROPYL-FUSED PYRROLIDINE-BASED INHIBITORS OF DIPEPTIDYL PEPTIDASE IV AND METHOD
IN/PCT/2002/01154/MUM A (PCT/US01/07151) (IN/PCT/2002/01154/MUM A (PCT/US01/07151))
Filed on 2002-08-23
Publication date 2005-03-04
Dipeptidyl peptidase IV (DP 4) inhibiting compounds are provided having the formula (I) where x is 0 or I and y is 0 or 1 (provided that x = I when y = 0 and x =0 when y = 1); n is 0 or 1; X is H or CN; and wherein R1, R2, R3 and R4 are as described herein. A method is also provided for treating diabetes and related diseases, especially Type 11 diabetes, and other diseases as set out herein, employing such DP4 inhibitor or a combination of such DP4 inhibitor and one or more of another antidiabetic agent such as metformin, glyburide, troglitazone, pioglitazone, rosiglitazone and/or insulin and/or one or more of a hypolipidemic agent and/or anti-obesity agent and/or other therapeutic agent.
Applicant
BRISTOL-MYERS SQUIBB CO.
P.O. BOX 4000, LAWRENCEVILLE-PRINCETON ROAD, PRINCETON, NJ 08543, U.S.A.
Inventor
1) ROBL JEFFREY A. 2) SULSKY RICHARD B. 3) AUGERI DAVID J. 4) MAGNIN DAVID R. 5) HAMANN LAWRENCE G. 6) BETEBENNER DAVID A.
International Information
Classification
C07D 209/52
Publication number
Application number