Dipeptidyl peptidase IV (DP 4) inhibiting compounds are provided having the formula (I) where x is 0 or I and y is 0 or 1 (provided that x = I when y = 0 and x =0 when y = 1); n is 0 or 1; X is H or CN; and wherein R1, R2, R3 and R4 are as described herein. A method is also provided for treating diabetes and related diseases, especially Type 11 diabetes, and other diseases as set out herein, employing such DP4 inhibitor or a combination of such DP4 inhibitor and one or more of another antidiabetic agent such as metformin, glyburide, troglitazone, pioglitazone, rosiglitazone and/or insulin and/or one or more of a hypolipidemic agent and/or anti-obesity agent and/or other therapeutic agent. 0 P.O. BOX 4000, LAWRENCEVILLE-PRINCETON ROAD, PRINCETON, NJ 08543, U.S.A. BRISTOL-MYERS SQUIBB CO. IN/PCT/2002/01154/MUM A (PCT/US01/07151) IN/PCT/2002/01154/MUM A (PCT/US01/07151) INDIA 2009-03-25T18:00:08Z 2005-03-04 2002-08-23 410225 C07D 209/52 1) ROBL JEFFREY A. 2) SULSKY RICHARD B. 3) AUGERI DAVID J. 4) MAGNIN DAVID R. 5) HAMANN LAWRENCE G. 6) BETEBENNER DAVID A. -2 0 1878 USA 2000-03-10 60/188,555 2005-03-04 0 2Hs4SVyF 2009-04-30T18:54:36Z 126644 1) ROBL JEFFREY A. 2) SULSKY RICHARD B. 3) AUGERI DAVID J. 4) MAGNIN DAVID R. 5) HAMANN LAWRENCE G. 6) BETEBENNER DAVID A 29197 BRISTOL-MYERS SQUIBB