TASTE MASKED CHEWABLE COMPOSITIONS OF SILDENAFIL CITRATE
2416/MUM/2007 A (2416/MUM/2007)
Filed on 2007-12-10
Publication date 2007-12-28
The present invention relates to chewable solid pharmaceutical composition comprising sildenafil citrate. Sildenafil citrate is a very bitter drug, hence the conventional tablets, comprise of a film coating for aesthetic appearance and acceptability. Chewable tablets are usually uncoated and hence there is a need to mask the bitter taste of sildenafil to ensure patient acceptability. The present invention achieves the taste masking of sildenafil citrate by using an ion-exchange resin which forms a complex and masks the bitter taste of sildenafil. The ion-exchange masked sildenafil complex is then incorporated with other excipients to formulate a chewable tablet using flavours and other ingredients.
Applicant
AJANTA PHARMA LTD
AJANTA HOUSE, CHARKOP, KANDIVALI (W), MUMBAI-400 067, Maharashtra India
Inventor
SINGH SHAILESH, AMIN DHANRAJ, GOUD MOHAN
International Information
Classification
C07D487/04
Publication number
NA