EPITOPE/PEPTIDE RECOGNIZED BY HLA-A2402-RESTRICTED EP-CAM-SPECIFIC CTL AND USE OF THE SAME
4061/DELNP/2006 A (4061/DELNP/2006)
Filed on 2006-07-14
Publication date 2007-06-22
A peptide consisting essentially of the amino acid sequence represented by SEQ ID N0:l; a peptide consisting essentially of the amino acid sequence represented by SEQ ID NO:2; or a mutant peptide consisting essentially of an amino acid sequence derived from the amino acid sequence represented by SEQ ID N0:l or 2 by addition, deletion or substitution of one or more amino acids, the peptide being capable of forming a complex with an HLA-A2402 molecule to be recognized by HLA-A2402-restricted cytotoxic T lymphocytes or induce such lymphocytes. Such a peptide is useful as a cancer vaccine for epithelial cancer patients having HLA-A2402.
Applicant
AICHI PREFECTURE
1-2, SANNOMARU 3-CHOME, NAKA-KU, NAGOYA-SHI, AICHI 460-8501, JAPAN Japan 2)OTSUKA PHARMACEUTICAL CO., LTD.
Inventor
KIYOTAKA KUZUSHIMA
International Information
Classification
A61K 39/00
Publication number
WO 2005/068632
Application date
2005-01-19
Application number
PCT/JP2005/000587