The present invention provides novel 2-anilinonicotinic acid derivatives, their preparation and anti-inflammatory activity which have the formulae I, II, III General Structure of Final Compounds wherein R is independently selected from the group consisting morpho line, pyrrolidine, piperidine, 2-methylpiperidine, 3-methylpiperidine, 4-methylpiperidine, 4-hydroxypiperidine, 2- ethylpiperidine, 2, 6-dimethylpiperidine, N-methylpiperazine, N-ethylpiperazine, N- hydroxyethylpiperazine, 2,6-dimethylmorpholine, thiomorpholine and like, their process for synthesis and their usefulness as anti-inflammatory activity in need, thereof.