The present invention relates to the use of an agonist of one or more of the nuclear receptors TR3, MESTOR and NOT for the preparation of a medicament for the treatment of cardiovascular disease, in particular in-sent rest enosis and/or vein-graft disease. The invention further relates to medical devices, such as stets and cuffs, that are coated with the agonist or in which the agonist is incorporated and which are for use in the treatment of in-sent rest enosis or vein-graft disease.