A METHOD FOR DETERMINING THE BIOLOGICAL ACTIVITY OF DEFIBROTIDE

Application 826/KOLNP/2004 published 2006-04-28, filed 2004-06-15
An enzymatic method for determining the biological activity of defibrotide is described. The method, which is based on the capacity of defibrotide to potentiate the enzymatic activity of plasmin, comprises the steps of: a) bringing into contact defibrotide, plasmin and a substrate specific for the plasmin which, by reaction with the plasmin, provides a measurable product and b) measuring the amount of product formed at successive times. (FIG.1)

Applicant

GENTIUM SPA
PIAZZA XX SETTEMBRE, 2, I-22089 VILLA GUARDIA, ITALY

Inventor

1. PORTA, Roberto; 2. CATTANEO, Franco; 3. FERRO, Laura

International Info

Classification: C12Q 1/37, 1/56, G01N 33/48
Publication Number: WO 2003/052130
Application Date: 2002-11-27

Priority Information

01830770.2 EUROPE 2001-12-17