POLYPEPTIDE VARIANTS
Application 972/KOLNP/2004 published 2006-05-05, filed 2004-07-13
The invention relates to the provision of oligomeric polypeptides (dimers, trimers, etc) comprising the ligand binding domains of cytokines which are linked via flexible polypeptide linker molecules. The linker molecules optionally comprise protease sensitive sites to modulate the release of biologically active cytokines when administered to a human or animal subject (FIG.1).
Applicant
ASTERION LIMITED.,
FIRTH COURT, WESTERN BANK, SHEFFIELD S10 2TN, GB.
Inventor
ROSS RICHARD ARTYMIUK PETER SAYERS JON
International Info
Classification: C07K 14/52
Publication Number: WO 03/062276
Application Date: 2003-01-24
Priority Information
0201679.8 GB 2002-01-25