BigPatents India

A process of preparation of Rofecoxib Transdermal Gel comprising the following steps. a. The thickening agent is dispersed in Purified Water b. The penetration enhancers and surfactants are mixed together. c. The preservatives and Disodium edetate are dissolved in Purified water. d. Rofecoxib is incorporated either by dissolving in the mixture of step (b) or micronised rofecoxib is incorporated directly into the dispersion of step (1). e. The solution of step (c) is added to step (d) and stirred properly. f. Isopropyl alcohol is added to the step (e) and homogenised till a very smooth dispersion is obtained. g. The fragrance is incorporated into the dispersion of step (f). h. The pH of the dispersion is adjusted in the range 4.0 to 6.8 with 20% solution of tromethamine in water. i. The weight is made up with purified water. Drawing: Nil Total Pages: 28.