PIPERIDINE DERIVATIVES USEFUL AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

Application 1142/MUMNP/2003 published 2006-05-05, filed 2003-12-15
The invention provides a compound of formula (I), wherein: T is C(O) or S(O)2; W is C(O) or S(O)2; X is CH2, O or NH; Y is CR<5> or N; R<1> is optionally substituted aryl or optionally substituted heterocyclyl; R<2> is hydrogen or C1-6alkyl; R<3> is hydrogen or optionally substituted C1-6alkyl; and R<4> is alkyl, optionally substituted aryl, optionally substituted aralkyl or optionally substituted heterocyclyl; that are modulators of chemokine (especially CCR3) activity and are especially useful for treating asthma and/or rhinitis. Drawing sheets. NIL Total Pages: 110 (FIG.-NIL)

Applicant

ASTRAZENECA AB
S-151 85 SODERTALJE, SWEDEN

Inventor

1. RICHARD EVANS 2. MATTHEW PERRY 3. BRIAN SPRINGTHORPE

International Info

Classification: C 07 D 401/04
Publication Number: WO 03/004487 A1

Priority Information

0116179.3 GREAT BRITAIN 2001-07-02
0123037.4 GREAT BRITAIN 2001-09-25