A CHEMOENZYMATIC PROCESS FOR THE STEREOSELECTIVE PREPARATION OF
Application 963/DEL/2005 published 2006-12-01, filed 2005-04-15
The present invention provides a chemoenzymatic process for the preparation of (R)-GABOB and (R)-carnitine employing lipase-mediated resolution of 3-hydroxy-4-tosyloxybutanenitrile as the key step. The drawing accompanying this specification represents the preparation of racemic 3-hydroxy-4-tosyloxybutanenitrile, its lipase-mediated kinetic resolution and its successful application in the preparation of (R)-GABOB and (R)-carnitine.
Applicant
1)COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
:ANUSANDHAN BHAWAN, RAFI MARG, NEW DELHI-110 001, INDIA.
Inventor
1)AHMED KAMAL 2)GOLLAPALLI BHASKER RAMESH KHANNA 3)TADIPARTHI KRISHNAJI 4)RONDLA RAMU
International Info
Classification: C07C229/00