OXAZOLIDIONONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
Application IN/PCT/2000/00658/MUM published 2006-01-06, filed 2000-11-23
Compounds of formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, wherein, for example, X is -O- or -S-; HET is an optionally substituted C-linked 5-membered heteroaryl ring containing 2 to 4 heteroatoms independently selected from N, O and S; Q is selected from, for example, formulae (Q1) and (Q2); R2 and R3 are independently hydrogen or fluoro; T is selected from a range of groups, for example, an N-linked (fully unsaturated) 5-membered heteroaryl ring system or a group of formula (TC5) wherein Rc is, for example, R13CO-, R13SO2- or R13CS-; wherein R13 is, for example, optionally substituted (1-10C)alkyl or R14C(O)O(1-6C)alkyl wherein R14 is optionally substituted (1-10C)alkyl; are useful as antibacterial agents; and processes for their manufacture and pharmaceutical compositions containing them are described. Drawing : NIL Total Pages: 185
Applicant
ASTRAZENECA AB
S-151 SODERTALJE, SWEDEN
Inventor
MICHAEL BARRY GRAVESTOCK
International Info
Classification: C07D 413/14, 417/14, C07F 9/6558, C07D 413/12, 487/08, 451/02, A61K 31/42, 31/44
Publication Number: WO 99/64417
Application Date: 1999-06-03
Priority Information
9812021.5 UNITED KINGDOM 1998-06-05
9820164.3 UNITED KINGDOM 1998-09-17
9826066.4 UNITED KINGDOM 1998-11-28