METHODS FOR ASSESSING THE INVASIVE POTENTIAL OF A CELL EMPLOYING CHIROMATIN ANALYSIS
Application 1364/MUMNP/2005 published 2006-05-12, filed 2005-12-05
Embodiments of the invention relate to compositions and methods for evaluating or estimating the invasive potential of cells and thereby differentiating between normal and cancerous cells in accordance with the susceptibility of the cellular chromatin to degradation or other modification by particular enzymes or agents. Chromatin within permeabilized normal and non-invasive cells, including chromatin strands removed therefrom, are more susceptible to degradation by endonucleases or proteinases than is the chromatin from invasive cells. Drawing: 06 Sheets. Total Pages: 43
Applicant
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
352 HENRY ADMINISTRATION BUILDING, 506 S, WRIGHT ST. URBANA, IL 61801.
Inventor
1. MANIOTIS ANDREW 2. FOLBERG ROBERT 3. KLARA VALYI-NAGY
International Info
Classification: C12Q 1/00
Publication Number: WO 2004/108951
Application Date: 2004-06-07
Priority Information
60/476,580 US 2003-06-06
60/511,543 US 2003-10-14
60/526,792 US 2003-12-04
60/574,437 US 2004-05-26