STABILIZED SOLID STATE POLYPEPTIDE PARTICLES
Application 941/KOLNP/2005 published 2006-05-12, filed 2005-05-20
The present invention includes solid-state polypeptide particles containing a polypeptide material that is stabilized against degradation at temperatures that approximate or exceed physiological conditions. In each embodiment, the polypeptide particles of the present invention incorporate a polypeptide material that is stabilized against degradation by one or more stabilizing conditions. Because the polypeptide particles of the present invention can be formulated to combine the additive effects of two or\more stabilizing conditions, where the polypeptide particles of the present invention include a stabilizing sugar, the amount of stabilizing sugar needed to achieve acceptable polypeptide stability is significantly reduced. (FIG. - 1)
Applicant
ALZA CORPORATION
1900 CHARLESTON ROAD, M10-3B MOUNTAIN VIEW CA 94043 USA
Inventor
1. BENTZ JOHANNA 2. KANG LING-LING
International Info
Classification: A61K 38/16
Publication Number: WO 2004/039392 A3
Application Date: 2003-10-28
Priority Information
60/422,289 US 2002-10-29