MODIFIED TERT PROMOTER WITH ENHANCED TUMOR-SPECIFICITY AND STRENGTH AND RECOMBINANT VECTOR COMPRISING THE SAME “
Application 937/MUMNP/2005 published 2006-05-19, filed 2005-08-23
The present invention relates to a transcriptional regulatory sequence with enhanced tumor-specificity and strength and a recombinant vector comprising the transcriptional regulatory sequence. More particularly, the present invention relates to a transcriptional regulatory sequence comprising a human telomere reverse transcriptase (hTERT) promoter linked to a nucleotide sequence that comprises one or more c-Myc binding sites and/or one or more Sp1 binding sites, and a recombinant vector comprising a certain gene that is operably linked to the above transcriptional regulatory sequence. Drawing : 55 Sheets Total Pages: 119 (FIG. - 1)
Applicant
1. YUN CHAE-OK 2. KIM JOO-HANG
1. #101, TAEHANG VILLA, 551-15, BANPO-DONG, SEOCHO-GU, SEOUL 137-807, KOREA 2. #C-1007, TWINBIL, MOK 5-DONG, YANGCHEON-GU, SEOUL 158-055, KOREA
Inventor
1. YUN CHAE-OK 2. KIM JOO-HANG
International Info
Classification: C12N 15/52,7/00, A61K 35/76
Publication Number: WO 2004/076668 A1
Application Date: 2004-02-27
Priority Information
10-2003-0012364 KOREA 2003-02-27