BigPatents India

Apparatus (100) for drug (36, 106) administration is provided, including an ingestible capsule (30, 102). The capsule (30, 102) includes a drug (36, 106), stored by the capsule (30, 102). An environmentally-sensitive mechanism (e.g., coating 104) is adapted to change a state thereof responsive to a disposition of the capsule (30, 102) within a gastrointestinal tract of a subject. A driving mechanism (e.g., driving mechanism 108), in response to a change of state of the environmentally-sensitive mechanism, is adapted to drive the drug (36, 106) directly through an endothelial layer of the gastrointestinal tract. Drawing : 29 Sheets Total Pages: 99 (FIG. - 1)