OPTIMIZED FC VARIANTS AND METHODS FOR THEIR GENERATION
Application 1288/MUMNP/2005 published 2006-05-19, filed 2005-11-21
The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants. A variant protein comprising an Fc variant of a wild-type Fc polypeptide, said Fc variant comprising at least one amino acid modification in the Fc region of said wild-type Fc polypeptide, wherein said variant protein exhibits altered binding to an FcyR as compared to the wild-type Fc polypeptide. Drawing : 47 Sheets Total Pages: 203
Applicant
XENCOR INC.
111 WEST LEMON AVENUE, MONROVIA, CA 91016, U.S.A.
Inventor
1. LAZAR GREGORY ALAN 2. CHIRINO ARTHUR J. 3. DANG WEI 4. DESJARLAIS JOHN RUDOLPH 5. DOBERSTEIN STEPHEN KOHL 6. HAYES ROBERT J. 7. KARKI SHER BAHUDUR 8. VAFA OMID
International Info
Classification: C07K 16/00, 16/30, 16/28, 16/24
Publication Number: WO 2004/099249
Application Date: 2004-03-26