“4-[PHENYL-PIPERIDIN –4-YLIDENE-METHYL)-BENZAMIDE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF PAIN, ANXIETY OR GASTROINTESTINAL DISORDERS

Application 1012/MUMNP/2003 published 2006-01-06, filed 2003-11-03
Compounds of general formula I R1 is selected from any one of phenyl, pyridinyl, pyrrolyl, thienyl, furanyl, imidazolyl, triazolyl, and pyridine N-oxide; where each R1 phenyl ring and R1 heteroaromatic ring may optionally and independently be further substituted by 1,2 or 3 substituents selected from straight and branched C1-C6 alkyl, NO2, CF3, C1-C6 alkoxy, chloro, fluoro, bromo, and iodo. The substitutions on the phenyl ring and on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain, anxiety and functional gastrointestinal disorders. Drawing : NIL Total Pages: 13

Applicant

ASTRAZENECA AB
S-151 85 SODERTALJE, SWEDEN

Inventor

1. WILLIAM BROWN 2. CHRISTOPHER WALPOLE 3. ZHONGYONG WEI

International Info

Classification: C07D 401/06, 401/14, 405/14, 409/14, 211/70, A61K 31/4545, A61P 25/04, 25/22
Publication Number: WO 02/094811
Application Date: 2002-05-16

Priority Information

0101768-0 SWEDEN 2001-05-18