: CENTRAL AIRWAY ADMINISTRATION FOR SYSTEMIC DELIVERY OF THERAPEUTICS
Application 1385/KOLNP/2004 published 2006-05-26, filed 2004-09-17
The present invention relates to methods and products for the transepithelial systemic delivery of therapeutics. In particular, the invention relates to methods and compositions for the systemic delivery of therapeutics by administering an aerosol containing conjugates of a therapeutic agent with an FcRn binding partner to epithelium of central airways of the lung. The methods and products are adaptable to a wide range of therapeutic agents, including proteins and polypeptides, nucleic acids, drugs, and others. In addition, the methods and products have the advantage of not requiring administration to the deep lung in order to effect systemic delivery. (FIG.NIL )
Applicant
THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
75 Francis Street, Boston, MA 02115, U.S.A.
Inventor
BLUMBERG, Richard, S. LENCER, Wayne, I. SIMISTER, Neil, E. BITONTI, Alan, J.
International Info
Classification: C12Q 1/68, C07H 21/04, C12N 15/85, A61K 31/00
Publication Number: WO 03/077834
Application Date: 2002-07-03
Priority Information
60/364,482 U.S.A. 2002-03-15