NAPTHTHALENE DERIVATIVES WHICH INHIBIT THE CYTOKINE OR BIOLOGICAL ACTIVITY OF MACROPHAGE MIGRATION INHIBITORY FACTOR

Application 1844/KOLNP/2004 published 2006-06-02, filed 2004-02-12
Where Y, R(1), R(8) and R(101), R(108) are as defined in the specification. Compounds of formula (II) and methods of inhibiting the cytokine or biological activity of Macrophage Migrating Inhibitory Factor (MIF) comprising contacting MIF with a compound of formula (I) are provided. The invention also relates to methods of treating diseases or conditions where MIF cytokine or biological activity is implicated comprising administration of compounds of formula (I), either alone or as part of a combination therapy. (FIG). Nil

Applicant

CORTICAL PTY LTD.,
COMMERCIAL OFFICE, INSTITUTE OF REPRODUCTION AND DEVELOPMENT, MONASH UNIVERSITY, 27-31 WRIGHT STREET, CLAYTON, VICTORIA 3168, AUSTRALIA.

Inventor

MORAND ERIC FRANCIS ISKANDER MAGDY NAGUIB DANYLEC BASIL

International Info

Classification: A61K 31/4184, A61K 31/585, C07C 205/59, C07C 229/70, C07C 255/37, C07C 309/60, C07C 309/75, C07C 333/04, C07C 43/225, C07C 43/23 , C07C 45/00 , C07C 45/46, C07C 59/58 , C07C 65/24, C07C 65/28 , C07C 69/94, C07D 235/26, C07D 307/83, C07D 319/18,C07D 403/12
Publication Number: WO 03/104178
Application Date: 2003-06-06

Priority Information

PS 2833 PS 2834 AU 2002-06-07