NITROANILINE-BASED ALKYLATING AGENTS AND THEIR USE AS PRODRUGS

Application 776/KOLNP/2005 published 2006-07-07, filed 2005-05-02
Nitroaniline-based unsymmetrical mustards of the general formula (I) are provided, together with methods of preparation and methods for their use as produgs for gene-dependent enzyme prodrug therapy (GDEPT) and cell ablation therapy in conjuction with nitroreductase enzymes as hypoxia selective cytotoxins and as anticancer agents. (FIG. 1)

Applicant

AUCKLAND UNISERVICES LIMITED
LEVEL 10, 70 SYMONDS STREET, AUCKLAND, NEW ZEALAND

Inventor

(1) DENY, WILLIAM ALEXANDER (2) ATWELL, GRAHAM J (3) YANG, SHANGLIN (4) WILSON, WILLIAM ROBERT

International Info

Classification: C07C 237/30; 309/66; 311/39; C07D 263/04; 295/13; A61K 31/18; 31/166; 31/357; 31/5375; A61P 35/00
Publication Number: WO04/033415A1-22.04.2004
Application Date: 2003-10-08

Priority Information

NZ 521851 NEW ZEALAND 2002-10-08