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Now, it is evident that insulin therapy is not a panacea for diabetes mellitus. This realization has promoted a great deal of research toward the development of more effective ways of treating the disese and has led to the discovery of several orally active agents. Metformin hydrochloride is an orally active hypoglycemic agent Root of Careya arborea was cleaned, dried and powdered. The experiment was undertaken with aqueous decoction of root of Careya arborea using metfomin hydrochloride as the standard. Micro HPLC was used as a tool for detection of metformin hydrochloride. The chromatograms obtained during HPLC Studies clearly represented the presence of this compound in the sample. Drawing: 02 Sheets. Total Pages: 08. Fig. Nil