CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS WITH ENHANCED EFFICACY
Application 593/KOLNP/2004 published 2006-06-16, filed 2004-05-06
The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and optionally contains additional rings. The compounds bind to chemokine receptors, including CXCR4 and CCR5, and demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV). (FIG. - Nil)
Applicant
ANORMED INC
NO 200 20353 64TH AVENUE LANGLEY BRITISH COLUMBIA V2Y 1N5 CANADA
Inventor
· BRIDGER GARY J · SKERLJ RENATO T · KALLE AL · HARWIG CURTIS · BOGUCKI DAVID · WILSON TREVOR · CRAWFORD JASON · MCEACHERN ERNEST J · ATSMA BEM · NAN SIQIAO · ZHOU YUANXI · SCHOLS DOMINIQUE · SMITH CHRISTOPHER DENNIS · DE FLURI MARIA ROSARIA
International Info
Classification: C07D 401/12
Publication Number: WO 03/055876 A1
Application Date: 2002-12-23
Priority Information
60/342,176 US 2001-12-21