10,10-DIALKYL PROSTANOIC ACID DERIVATIVES AS AGENTS FOR LOWERING INTRAOCULAR PRESSURE

Application 1417/KOLNP/2005 published 2006-09-01, filed 2005-07-21
The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of a compound represented by the general formula (I); wherein the dashed line indicates the presence or absence of a bond, the hatched wedge indicates the &agr; (down) configuration, and the solid triangle indicates the &bgr; (up) configuration; B is a single, double, or triple covalent bond; n is 0-6; X is CH2, S or O; Y is any pharmaceutically acceptable salt of C02H, or C02R, CONR2, CONHCH2CH20H, CON(CH2CH2OH)2,CH2OR, P(O)(OR)2, CONRSO2R, SONR2, or formula (Ia) R is H, C1-6 alkyl or C2-6 alkenyl; R2 and R3 are C1-6 linear alkyl which may be the same or different, and may be bonded to each other such that they form a ring incorporating the carbon to which they are commonly attached (FIG. - nil)

Applicant

ALLERGAN INC
2525 DUPONT DRIVE T2-7H IRVINE CA 92612 USA

Inventor

1. DONDE YARIV 2. NGUYEN JEREMIAH H

International Info

Classification: A61K
Publication Number: WO 04/071428 A2
Application Date: 2004-02-06

Priority Information

10/365,369 US 2003-02-11