FUSION CONSTRUCTS AND USE OF SAME TO PRODUCE ANTIBODIES WITH INCREASED RECEPTOR BINDING AFFINITY AND EFFECTOR FUNCTION
Application 1628/KOLNP/2005 published 2006-09-01, filed 2005-08-16
The present invention relates to the field of glycosylation engineering of proteins. More particularly, the present invention relates to nucleic acid molecules, including fusion constructs, having catalytic activity and the use of same in glycosylation engineering of host cells to generate polypeptides with improved therapeutic properties, including antibodies with increased Fc receptor binding and increased effector function (FIG.nil)
Applicant
GLYCART BIOTECHNOLOGY AG.,
WAGISTRASSE 18, SCHLIEREN, CH 8952, ZURICH, SWITZERLAND.
Inventor
UMANA PABLO BRUENKER PETER FERRARA CLAUDIA SUTER TOBIAS
International Info
Classification: C12N 9/10
Publication Number: WO 04/065540
Application Date: 2004-01-22
Priority Information
60/441,307 USA 2003-01-22
60/491,254 USA 2003-07-31
60/495,142 USA 2003-08-15