HALOALKYL CONTAINING COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS
Application 1996/KOLNP/2005 published 2006-09-01, filed 2005-10-07
The application is directed to haloalkyl-substituted compounds of formula (I) wherein R7 represents haloalkyl; and R1, R2, R3, R4, R5, R6 and R8 are as defined in the claims. The compounds are inhibitors of cysteine proteases, in particular cathepsins B, K, L, F and S and are therefore useful in treating diseases mediated by these proteases. Pharmaceutical compositions containing these compounds and their use are also disclosed. (FIG.nil).
Applicant
AXYS PHARMACEUTICALS INC.
180 KIMBALL WAY, SO. SAN FRANCISCO, CA 94080, U.S.A
Inventor
(1) LINK JOHN O (2) MOSSMAN CRAIG J (3) WOO SOON H (4) ZIPFEL SHEILA M
International Info
Classification: C07C 317/00
Publication Number: WO05/028429A2 – 31.03.2005
Application Date: 2004-09-17
Priority Information
60/504,680 U.S.A 2003-09-18
60/561,062 U.S.A 2004-04-09