BigPatents India

A process for preparation of a pharmaceutical composition for oral use with desired dissolution profile and stability comprises steps of manufacturing, a core containing a pharmacologically effective acid labile compound, and/or its alkaline salts, optionally with alkaline reacting substance. An inert subcoating layer which is a first coating layer, coated on the core, comprising film forming materials such as hydroxypropylmethyl cellulose, microcryslline cellulose, polyvinylpyrrolidone, hydroxymethylcellulose, hydroxyethylcellulose, dextran and optionally water insoluble particles such as magnesium oxide, sililic anhydride, calcium silicate, magnesium hydroxide, magnesium carbonate, aluminium hydroxide, calcium stearate and magnesium stearate. Second coat, termed as a seal coat, comprising of a mixture of polymers like hydroxypropylmethyl cellulose, cellulose acetate phthalate, and ethyl cellulose over the subcoat. An enteric coating layer surrounding said seal coat layer, wherein the seal coat layer isolates the core and the subcoat layer from the enteric coating layer. Drawing: NIL Total Pages: 18 Fig. Nil