BigPatents India

The present invention describes a process for manufacture of an oral sustained release tablet dosage form having one or more drugs in a non-gas generating, floating, swellable and bioadhesive, novel carrier composition, comprising, one or more of solid compatible drugs such as Ofloxacin; Acyclovir; Simvastatin; Carbamazepine; Niacin; Cefixime; Venlafaxine which are mainly used for sustained release formulations preferably, once daily formulations in a pharmaceutically effective amount, and a carrier composition comprising, high viscocity sodium carboxy methyl cellulose; a swelling bioadhesive; gellan gum; one or more of hydrophilic water soluble polymers; and other excipients; sieving individual ingredients and blending together all the ingredients of the tablet composition, followed by compressing of the blend into a tablet. The process of the present invention is particularly useful for orally administering the group of drugs having an absorption window in the specific regions of stomach or upper parts of the small intestine, in pharmaceutically effective amount. Drawing: NIL Total Pages: 24 Fig. Nil