: “ ONE POT CONVERSION OF D-ERYTHRONOLACTONE TO ENANTIOMERICALLY PURE ALKYL
Application 2174/DEL/2004 published 2006-08-18, filed 2004-11-01
The present invention provides an improved synthesis of enantiomerically pure Alkyl (Methyl or Ethyl) (s)-4-Bromo-3-hydroxybutanoate has been achieved. The synthetic strategy features use of D-erythronolactone as the starting substrate. Its ready conversion to Alkyl 2,4- dibromo-3- hydroxybutanoate and selective C-2 debromination affords optically pure Alkyl (S) –4-Bromo-3-hydroxybutanoate. The title compound is a key intermediate in arriving at the substrates for HMG-coA reductase inhibitors.
Applicant
COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESERCH
Rafi Marg, New Delhi-110001.
Inventor
1. INDRAPAL SINGH AIDHEN 2. MUKUND KESHAV GURJAR 3. SAKKARAPALAYAM MURUGESAN MAHALINGAM
International Info
Classification: CO7C 67/00