NOVEL THIOPHENE AMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATING COMPLEMENT-MEDIATED DISEASES AND CONDITIONS
Application 1730/KOLNP/2004 published 2006-08-18, filed 2004-11-16
Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula (I) or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R1, R2, R3, R4 and R7 are defined in the specification, Z is SO or SO2, and Ar is an aromatic or heteroaromatic group as defined herein. (FIG.1)
Applicant
3-DIMENSIONAL PHARMACEUTICALS, INC.
THREE LOWER MAKEFIELD CORPORATE CENTER, 1020 STONY HILL ROAD, SUITE 300, YARDLEY, PA 19067, UNITED STATES OF AMERICA
Inventor
SUBASINGHEE NALIN; KHALIL EHAB; LEONARD KRISTI; ALI FARAH; HUFNAGEL HEATHER RAE; TRAVINS JEREMY M; BALLENTINE SHELLEY K; WILSON KENNETH T; CUMMINGS MAXWELL D; PAN WENXI; GUSHUE JOAN; MEEGALLA SANATH; WALL MARK; CHEN JINSHENG; RUDOLPH M JONATHAN; HUANG HUI
International Info
Classification: C07D 333/32, 333/38, 413/14, 495/04
Publication Number: WO 2003/099805
Application Date: 2003-05-28
Priority Information
60/383,130 USA 2002-05-28