: “An Improved Process For The Preparation Of 1-2[Dimethylamino-
Application 232/DEL/2001 published 2006-07-21, filed 2001-02-28
The present invention relates to an improved process for the preparation of 1-2[Dimethylamino-(4-Methoxypheny1]-cyclohexanol of formula 1. The product is commonly known as Venlafaxine and also as effexor. In the process a one pot synthesis of compound of formula 1 from 1[Cano(4-methoxypheny1)-cyclo-hexanol having formula 2 is carried out in presence of formylating agent such as formalin, catalyst-raney nickel and protic solvent. The compound of formula 2 is prepared by a single step conversion comprising the condensation of 4-methoxyphenylacetonitrile with cyclohexanone in the presence of a convenient base like sodium hydroxide..
Applicant
Council of Scientific and Industrial Research.
Rafi Marg, New Delhi – 1100 01, INDIA.
Inventor
Subhash Prataprao Chavan Subhash Krishnaji Kamat Latha Sivadasan Kamalam Balakrishanan Dushant Anandrao Khobragade Thottappillil Ravindranathan Mukund Keshao Gurjar Uttam Ramrao Kalkote.
International Info
Classification: C 07 C 213/10 C 07 C 217/74