. “PREPARATION OF SUBMICRON SIZED PARTICLES WITH POLYMORPH CONTROL AND NEW POLYMORPH OF ITRACONAZOLE”
Application 862/DEL NP/2005 published 2006-07-21, filed 2005-03-04
The present invention provides a method of preparing particles with polymorph and size control of a pharmaceutical compound, the method including the steps of: (1) providing pharmaceutical compound in a first phase; (2) seeding the compound; (3) causing a phase change in the pharmaceutical compound to a second phase of a desired polymorphic form; and (4) wherein the mean particle size of the particles is less than 7µm. The present invention further provides a polymorphic form of itraconazole.
Applicant
BAXTER INTERNATIONAL, INC
ONE BAXTER PARKWAY, DEERFIELD, ILLINOIS, 60015, USA.
Inventor
: JANE WERLING JAMES E. KIPP RAJARAM SRIRAM MARK J. DOTY CHRISTINE L. REBBECK JOSEPH CHUNG TAK WONG : NO
International Info
Classification: A 61 K 9/00
Publication Number: WO 2004/054500
Application Date: 2003-08-04
Priority Information
10/213 US 2002-08-05
352 10/246 US 2002-09-17