SMALL ORGANIC MOLECULE REGULATORS OF CELL PROLIFERATION
Application 749/DELNP/2004 published 2006-07-21, filed 2004-03-24
The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in Figures 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.
Applicant
CURIS Inc.
:61 Moulton Street, Cambridge, MA 02138 U.S.A.
Inventor
BAXTER, Anthony David BOYD, Edward Andrew FRANK-KAMENETSKY PORTER, Jeffery PRICE, STEPHEN RUBIN, LEE L. STIBBARD, John Harry Alexander
International Info
Classification: A61K 31/381
Publication Number: WO 2003/027234
Application Date: 2002-09-18
Priority Information
09/964,276 U.S.A. 2001-09-26