PROCESS FOR THE PREPARATION OF MODAFINIL OF FORMULA

Application 1387/MUM/2004 published 2006-07-21, filed 2004-12-21
Process for the preparation of Modafinil which is a CNS stimulant and used for the treatment of narcolepsia. The process comprises reacting 2-[(diphenylmethyl)thio]acetic acid with alcohols, in presence of catalytic amount of inorganic acid or organic acid at reflux temperature of alcohol to obtain corresponding ester which is reacted with ammonia to give 2-[(diphenylmethyl)thio]acetamide, which is reacted with hydrogen peroxide to produce Modafinil. Drawing: NIL Sheets. Total Pages: 17. Fig. Nil

Applicant

ALEMBIC LIMITED
ALEMBIC ROAD, VADODARA-390 003, GUJARAT, INDIA.

Inventor

1. BHATT SURENDRA B 2. PATEL JITEN R 3. PANCHASARA DINESH 4. SHAH HETAL R 5. DEO KESHAV 6. KANSAL VINOD KUMAR

International Info

Classification: A61K 31/400