METHODS AND DOSAGE FORMS FOR INCREASING SOLUBILITY OF DRUG COMPOSITIONS FOR CONTROLLED DELIVERY
Application 1990/KOLNP/2004 published 2006-07-21, filed 2004-12-27
Dosage forms and devices for enhancing controlled delivery of pharmaceutical agents by use of a drug core composition containing a polymer carrier (e.g. polyethylene oxide) and a surfactant (e.g. polyoxyl stearate, poloxamer) that increases the solubility of the pharmaceutical agent are described. The present invention provides a means of delivering high doses of lowly soluble drug in oral drug delivery systems that are convenient to swallow, for once-a-day administration. (FIG. 5)
Applicant
ALZA CORPORATION
JOHNSON & JOHNSON, ONE JOHNSON & JOHNSON PLAZA, WH3221, NEW BRUNSWICK, NJ 08933-7003, UNITED STATES OF AMERICA
Inventor
EDGREN DAVID; WONG PATRICK S.L.; JAO FRANK; SKLUZACEK ROBERT; LI SHU; LAM ANDREW; BHATTI GURDISH; LI SHAOLING; TO WINNIE; AYER ATUL
International Info
Classification: A61K 9/00; A61P 25/08
Publication Number: WO 04/002447
Application Date: 2003-06-26
Priority Information
60/392,128 USA 2002-06-26