BigPatents India

The present invention relates to a process for the preparation of human platelet aggregation and lipoxygenase inhibitor. In particular human platelet aggregation inhibitor and a lipoxygenase inhibitor from a fungal source. Platelet aggregation and blood clotting results in the blockage of capillaries and arteries. This leads to heart attacks and paralytic attacks if the arteries in the brain are blocked. Inhibitors against platelet aggregation thus have a great potential application in the medical sector. Lipids are highly vulnerable to oxidation which can be initiated by enzymatic and non enzymatic processes. The enzymatic process is initiated by Lioxygenases, which are responsible for the oxygenation of polyunsaturated fatty acids such as linoleic, linolenic and arachidonic acid. These enzymes are found to be responsible for just for the deterioration, rancidity and loss of flavour in food materials and also for various diseases in the human body, such as Parkinson"s disease, cataractogenesis, endotoxin liver injury, and myocardial infraction. Inhibitors against these enzymes thus have a potential application in both the food and medical sector.