USE OF DIGOXIN IMMUNE FAB FOR THE REGULATION OF SODIUM/POTASSIUM ATPASE ACTIVITY IN PREECLAMPTIC AND ECLAMPTIC PATIENTS

Application 248/KOLNP/2005 published 2006-06-09, filed 2005-02-23
A method of regulating a preeclamptic/eclamptic patient's sodium/potassium ATPase activity includes the administration of digoxin immune Fab (ovine). Digoxin immune Fab (ovine) binds with the endogenous digitalis-like factor to prevent it from interfering with the functioning of the sodium/potassium ATPase, thereby allowing the patient's intracellular sodium and calcium to return to a more normal level. A method of controlling preeclampsia is also disclosed that includes the steps of providing a supply of digoxin immune Fab (ovine), calculating an appropriate dosage of the digoxin immune Fab (ovine) based on a patient's weight and using an assumed endogenous digitalis-like factor level, administering the appropriate dosage as an intravenous bolus, and repeating the administration of the appropriate dosage on a fixed schedule. (FIG). 1

Applicant

ADAIR, CHARLES, DAVID.,
22 MOUNTAIN ORCHARD PATH, SIGNAL MOUNTAIN, TENNESSEE 37377 USA.

Inventor

ADAIR, CHARELS, DAVID

International Info

Classification: A61K 39/395, A61P 9/12
Publication Number: WO 04/011028
Application Date: 2003-07-24

Priority Information

10/202,957 US 2002-07-25
10/292,338 US 2002-11-12