PRION PROTEIN LIGANDS AND METHODS OF USE
Application 1106/KOLNP/2005 published 2006-06-09, filed 2005-06-09
Ligands that bind to prion proteins and methods for using the ligands for detecting or removing a prion protein from a sample, such as a biological fluid or an environmental sample. The ligands are capable of binding to one or more forms of prion protein including cellular prion protein (PrPc), infectious prion protein (PrPsc), and recombinant prion protein (PrPr). Prions from various species, including humans and hamsters, are bound by the ligands. Also provided is a method of treating or retarding the development of a prion-associated pathology in a subject. (FIG. -NIL)
Applicant
THE AMERICAN NATIONAL RED CROSS & NORTH CAROLINA STATE UNIVERSITY
15601 CRABBS BRANCH WAY ROCKVILLE MD 20855 USA & 2401 RESEARCH DRIVE SUITE 1122 RALEIGH NC 27695-8212 USA
Inventor
1. HAMMOND DAVID J 2. LATHROP JULIA T 3. CERVENAKOVA LARISA 4. CARBONELL RUBEN G
International Info
Classification: C12N
Publication Number: WO 04/050851 A2
Application Date: 2003-12-03
Priority Information
60/430,423 US 2002-12-03