“A PHARMACEUTICAL COMPOSITION ”
Application IN/PCT/2001/00576/DEL published 2006-06-09, filed 2001-07-03
Compounds and pharmaceutical compositions active against hepatitis B virus are provided, as is a method for the treatment of hepatitis B virus infection in humans and other host animals is provided comprising administering an effective amount of a beta -L-(2' or 3'- azido)-2',3'-dideoxy-5-fluorocytosine of formula (I) wherein R is H, acyl, monophosphate, diphosphate, or triphosphate, or a stabilized phosphate derivative (to form a stabilized nucleotide prodrug), and R' is H, acyl, or alkyl.
Applicant
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE. THE UAB RESEARCH FOUNDATION EMORY UNIVERSITY
3 rue Mechel-Ange, F-75794 Paris Cedex 16, France, 1825 University Boulevard, Room 113, MJH, Birmingham, AL 35294-2010, United States of America 1380 S. Oxford Road, Atlanta, GA 30322, United States of America.
Inventor
Gosselin, Gilles, Imbach, Jean-louis, Sommadossi, Jean-Pierre and Schinazi, Raymond, F.
International Info
Classification: A 61 P 31/18 A 61 K 31/495
Publication Number: WO 00/26225
Application Date: 1999-11-05
Priority Information
60/107,116 USA 1998-11-05
60/115,653 USA 1999-01-13