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A serum cholesterol lowering agent or a preventive or therapeutic agent for atherosclerosis, which each comprises a combination of a compound represented by the following general formula (I) or a pharmaceutically acceptable salt thereof with a cholesterol biosynthesis inhibitor and/or a fibrate type cholesterol lowering agent. (I) (b) (a) [In the formula, A1, A3, and A4 each is hydrogen, a group represented by the formula (b), or a group represented by the formula (a), provided that at least one of these is a group represented by the formula (a); A2 is C1-5 alkyl, etc.; and n, p, q, and r each is an integer of 0, 1, or 2.] (FIG. - Nil)