METHOD FOR IMPROVING STABILITY AND SHELF-LIFE OF LIPOSOME COMPLEXES

Application 2616/KOLNP/2005 published 2006-10-20, filed 2005-12-16
A method for preparing a stable cell-targeting complex comprising a ligand and a cationic liposome encapsulating a therapeutic or diagnostic agent comprises (a) combining the complex with a solution comprising a stabilizing amount of sucrose and (b) lyophilizing the resultant solution to obtain a lyophilized preparation; wherein, upon reconstitution, the preparation retains at least about 80% of its pre-lyophilization activity. (FIG. Nil)

Applicant

GEORGETOWN UNIVERSITY,
37TH & O STREETS, N.W., WASHINGTON, DC 20057, USA.

Inventor

CHANG, ESTHER, H PIROLLO, KATHLEEN, F

International Info

Classification: A61K 9/127
Publication Number: WO 05/000271
Application Date: 2004-06-04

Priority Information

60/475,500 USA 2003-06-04