“T CELL REGULATORY GENES AND METHODS OF USE THEREOF“
Application 2280/DELNP/2003 published 2006-01-20, filed 2003-12-29
A genetic locus and corresponding family of proteins associated with regulation of immune function and cell survival are provided. These genes encode cell surface molecules with conserved IgV and mucin domains. The locus comprising the TIM family is genetically associated with immune dysfunction, including asthma. Furthermore, the TIM gene family is located within a region of human chromosome 5 that is commonly deleted in malignancies and myelodysplastic syndrome. Polymorphisms in the gene sequences are associated with the development of airway hyperreactivity and allergic inflammation, and T cell production of IL-4 and IL-13. The proteins include the human hepatitis A cellular receptor, hHAVcr-1.
Applicant
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
1705 EL CAMINO REAL, PALO ALTO, CALIFORNIA 94306- 1106
Inventor
1. MCINTIRE, JENNIER,JONES 2. DEKRUYFF, ROSEMARIE H. 3. UMETSU, DALE, T. 4. FREEMAN, GORDON J. 5. KUCHROO, VIJAY
International Info
Classification: A61K 39/00
Publication Number: WO 03/002722
Application Date: 2002-07-01
Priority Information
60/302,344 US 2001-06-29