BigPatents India

The present invention relates to a topical formulation and a process for the preparation thereof, which can be used in management (including prevention) of peripheral vascular disease and conditions and syndromes causing or likely to cause peripheral vascular disease, particularly those involving microcirculation or microvasculature of hands and feet. The topical formulation of the present invention is helpful in diseases like cold injuries, diabetes mellitus, Berger’s disease, Raynaud’s phenomenon, burns and other vasospastic, vasodestructive or ischemic conditions related to infective, autoimmune, neural vascular, degenerative or inflammatory disorders. The topical formulation, on multiple applications to the overlying skin, increases the local blood supply, and may reduce inflammation, intravascular thrombosis & clotting, and viscosity of the blood, thus, improving the blood flow in the lesion area. The formulation helps in relieving the painful ischemic symptoms, in preventing or reducing further damages to the tissues, and in preventing or reducing oxidation injury. It also causes early healing and increase work efficiency of the body part. The formulation has no significant adverse-effects and can be used in cold and dry weather.