HUMAN IL-1 BETA ANTAGONISTS
Application 1438/KOLNP/2005 published 2006-09-15, filed 2005-07-25
The present invention encompasses isolated antibodies, or antigen-binding portions thereof, that specifically bind mature human IL-1 Beta. These antibodies, or antigen-binding portions thereof, generally exhibit high binding affinities (low kooff values), reduced deamidation compared to the native antibody, and can be used to treat various diseases such as rheumatoid arthritis, osteoarthritis, or neuroinflammation (FIG. - nil)
Applicant
APPLIED MOLUECULAR EVOLUTION INC
3520 DUNHILL STREET SAN DIEGO CALIFORNIA 92121 USA
Inventor
1. CRAIG DUANE DICKINSON 2. ALAIN PHILIPPE VASSEROT 3. JEFEERY DEAN WATKINS 4. JIRONG LU
International Info
Classification: C07K 16/24,C12N 15/13,15/85,5/10,A61K 39/395,A61P 19/02,37/00,25/00
Publication Number: WO 04/067568 A3
Application Date: 2004-01-21
Priority Information
60/442,798 US 2003-01-24