BigPatents India

A process for the solid state synthesis of enantiopur p-aminoalcohols from racemic epoxides The present invention relates to a process for the solid state synthesis of enantiopure J3-aminoalcohols from racemic epoxides. The process relates to a process for the solid state synthesis of enantiopure P-aminoalcohols from racemic epoxides by the dynamic kinetic resolution involving enantiodifferentiating recemisation in crystalline cyclodextrin complexes. The invention discloses a process for the solid state synthesis of enantiopure p-aminoalcohols from racemic epoxides by dynamic kinetic resolution involving enantiodifferentiating racemisation n crystalline cyclodextrin complexes, which comprises synthesis of various racemic aryloxyepoxides to obtain their inclusion complex with cyclodextrins, reacting the epoxide of the cyclodextrin complex with amines under solid state conditions, extracting the product with solvent, removing the solvent and amine in cacuo and purifying the product p-aminoalcohol by the formation of hydrochloride.