INTEGRIN TARGETTED IMAGING AGENTS
Application 1078/KOLNP/2004 published 2006-12-01, filed 2004-07-28
Emulsions preferably of nanopartides formed from high boiling liquid perfluorochemical substances, said particles coated with a lipid/surfactant coating are made specific to regions of activated endothelial cells by coupling said nanoparticles to a ligand specific for QvP3 integrin, other than an antibody. The nanoparticles may further include biologically active agents, radionuclides, or other imaging agents. (FIG. Nil)
Applicant
BARNES JEWISH HOSPITAL AND BRISTOL-MYERS SQUIBB MEDICAL IMAGING, INC.
600 S. TAYLOR, ST. LOUIS, MO 63110, UNITED STATES OF AMERICA AND 331 TREBLE COVE ROAD, NORTH BILLERICA, MA 01862, UNITED STATES OF AMERICA
Inventor
LANZA GREGORY; WICKLINE SAMUEL A; HARRIS TOM
International Info
Classification: A61K 47/48
Publication Number: WO 03/062198
Application Date: 2003-01-23
Priority Information
60/351390 USA 2002-01-24