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Application 1963/KOLNP/2005 published 2006-12-22, filed 2005-10-04
Disclosed are compounds of formula I as modulators of peroxisome proliferator activated receptors (PPARs) for the treatment of metabolic diseases such as obesity: wherein Ar1 is selected from the group consisting of a monocyclic heteroarornatic ring structure and a bicyclic heteroaromatic ring structure; Ar2 is selected from the group consisting of a monocyclic, a bicyclic, and a tricyclic carbocyclic aryl ring structure R1 is selected from the group consisting of alkyl, optionally substituted a five-membered or six-membered heteroarylring or a six-membered aryl ring, optionally substituted R2 is selected from the group consisting of hydrogen; alkyl, optionally substituted a five-membered or six-membered heteroaryl ring or a six-membered aryl ring, optionally substituted cyano; nitro; an amino; an amido; perhaloalkyl; and halogen; R3 is selected from the group consisting of hydrogen; alkyl, optionally substituted and B is a five-membered or six-membered heteroaryl ring, or -(CH2)j-C(O)OR4, wherein j is 0 or I 1 when Ar2 is a bicyclic or tricyclic carbocyclic ring structure and j is 1 when Ar2 is a monocyclic carbocyclic ring structure; and R4 is selected from the group consisting of hydrogen; alkyl, optionally substituted a five-membered or six-membered heteroaryl ring or a six-membered aryl ring, optionally substituted. The optional substituents are as defined in claim 1. (FIG). nil

Applicant

KALYPSYS, INC.,
10420, WATERIDGE CIRCLE, SAN DIEGO, CA 92121, USA.

Inventor

LIU, KEVIN ZHAO, CUNXIANG

International Info

Classification: A61K 31/305, 31/4402, 31/426, 31/421, C07D 239/42, 213/38, 277/82, 263/58, A61P 3/04
Publication Number: WO 04/093879
Application Date: 2004-04-07

Priority Information

60/464,581 USA 2003-04-17