"PALATABLE ORAL SUSPENSION AND METHOD"
Application 2404/DELNP/2004 published 2007-01-12, filed 2004-08-18
A drug formulation in the form of a dry powder is provided which when mixed with water forms a palatable oral suspension substantially free of bitter taste, the dry powder being formed of a drug, preferably des-quinolone, which in solution has a bitter taste, and a pH modifying agent which is preferably an alkaline material such as L-arginine, where upon mixing the dry-powder in water causes the drug to have reduced solubility or precipitate in-situ to form a palatable oral suspension essentially free of bitter taste. An oral suspension, methods for making same and a method for masking the bitter taste of drugs employing one or more pH modifying agents are also provided.
Applicant
1)BRISTOL - MYERS SQUIBB COMPANY
:P.O. BOX 4000, ROUTE 206 AND PROVINCE LINE ROAD, PRINCETON NEW JERSEY 08543-4000, USA U.S.A.
Inventor
1)ISMAT ULLAH 2)GARY J. WILEY
International Info
Classification: A61K9/0026
Publication Number: WO 2003/077842
Application Date: 2003-03-06
Priority Information
60/363 U.S.A. 2002-03-12